査読付き研究論文

Rise Kurokawa, Chatherine Silas Mtali, Innocent John Daniel, Thorbjorg Einarsdottir, Omnia Reda, Nobuko Irie, Wajihah Sakhor, Koki Niimura, Mitsuyoshi Takatori, Kenji Sugata, Chanidapa Adele Tye, Yorifumi Satou, Masahiro Ono, Takushi Nomura, Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity. PLOS Pathog, 2026, 22(1):e1013866
https://doi.org/10.1371/journal.ppat.1013866

Daniel Thoresen, Kenta Matsuda, Akane Urakami, Mya Myat Ngwe Tun, Takushi Nomura, Meng Ling Moi, Yuri Watanabe, Momoko Ishikawa, Trang Thi Thu Hau, Hiroyuki Yamamoto, Yuriko Suzaki, Yasushi Ami, Jonathan F Smith, Tetsuro Matano, Kouichi Morita, Wataru Akahata, A tetravalent dengue virus-like particle vaccine induces high levels of neutralizing antibodies and reduces dengue replication in non-human primates. J Virol, 2024, 98(5):e0023924
https://doi.org/10.1128/jvi.00239-24

Midori Nakamura-Hoshi, Hiroshi Ishii, Takushi Nomura, Masako Nishizawa, Trang Thi Thu Hau, Nozomi Kuse, Midori Okazaki, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Takeshi Yoshida, Kenzo Yonemitsu, Yuriko Suzaki, Yasushi Ami, Hiroyuki Yamamoto, Tetsuro Matano, Prophylactic vaccination inducing anti-Env antibodies can result in protection against HTLV-1 challenge in macaques. Molecular Therapy, 2024, 32(7):2328-2339
https://doi.org/10.1016/j.ymthe.2024.05.020

Midori Nakamura-Hoshi, Takushi Nomura, Masako Nishizawa, Trang Thi Thu Hau, Hiroyuki Yamamoto, Midori Okazaki, Hiroshi Ishii, Kenzo Yonemitsu, Yuriko Suzaki, Yasushi Ami, Tetsuro Matano, HTLV-1 Proliferation after CD8 + Cell Depletion by Monoclonal Anti-CD8 Antibody Administration in Latently HTLV-1-Infected Cynomolgus Macaques. Microbiology Spectrum, 2023, 11(4):e01518-23
https://doi.org/10.1128/spectrum.01518-23

Trang Thi Thu Hau, Masako Nishizawa, Shigeyoshi Harada, My Ha Phan, Yoshiaki Kanno, Takushi Nomura, Saori Matsuoka, Ai Kawana-Tachikawa, William W Hall, Tetsuro Matano, Lan Anh Thi Nguyen, Hiroyuki Yamamoto, Association of envelope-specific B-cell differentiation and viral selective pressure signatures in HIV-1 CRF01_AE infection. AIDS, 2022, 36(12):1629-1641
https://doi.org/10.1097/QAD.0000000000003323

N.A.A. Ntim, H. Ishii, M. Jomori, H. Yamamoto, T. Matano, T. Nomura, Hierarchy of multiple viral CD8(+) T-cell epitope mutations in sequential selection in simian immunodeficiency infection, Biochem Biophys Res Commun, 2022, 607:124-130.
https://doi.org/10.1016/j.bbrc.2022.03.108

H. Ishii, K. Terahara, T. Nomura, M. Okazaki, H. Yamamoto, T. Shu, H. Sakawaki, T. Miura, D.I. Watkins, T. Matano, Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag/Vif-specific CD8(+) T cells but not CD4(+) T cells, Mol Ther, 2022, in press
https://doi.org/10.1016/j.ymthe.2022.02.023

H. Ishii*, T. Nomura*, H. Yamamoto, M. Nishizawa, T.T. Thu Hau, S. Harada, S. Seki, M. Nakamura-Hoshi, M. Okazaki, S. Daigen, A. Kawana-Tachikawa, N. Nagata, N. Iwata-Yoshikawa, N. Shiwa, T. Suzuki, E.S. Park, M. Ken, T. Onodera, Y. Takahashi, K. Kusano, R. Shimazaki, Y. Suzaki, Y. Ami, T. Matano, Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8(+) T cell responses, Cell Rep Med, 2022, 3(2):100520.
https://doi.org/10.1016/j.xcrm.2022.100520

T.T.T. Hau, Y. Kanno, M. Nishizawa, T. Nomura, T. Matano, H. Yamamoto, Nef-specific CD107a(+) CD4(+) T-cell responses in a rhesus macaque (Macaca mulatta) showing partial simian immunodeficiency virus control following passive neutralizing antibody infusion, J Med Primatol, 2022, 51(1):56-61.
https://doi.org/10.1111/jmp.12551

T. Nomura, H. Yamamoto, M. Nishizawa, T.T.T. Hau, S. Harada, H. Ishii, S. Seki, M. Nakamura-Hoshi, M. Okazaki, S. Daigen, A. Kawana-Tachikawa, N. Nagata, N. Iwata-Yoshikawa, N. Shiwa, S. Iida, H. Katano, T. Suzuki, E.S. Park, K. Maeda, Y. Suzaki, Y. Ami, T. Matano, Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques, PLoS Pathog, 2021, 17(7):e1009668.
https://doi.org/10.1371/journal.ppat.1009668

Y. Kanno, T.T.T. Hau, R. Kurokawa, T. Nomura, M. Nishizawa, T. Matano, H. Yamamoto, Late-phase dominance of a single epitope-specific CD8+ T-cell response in passive neutralizing antibody-infused simian immunodeficiency virus controllers, AIDS, 2021, 35(14):2281-2288.
https://doi.org/10.1097/QAD.0000000000003013

M. Nakamura-Hoshi, Y. Takahara, S. Matsuoka, H. Ishii, S. Seki, T. Nomura, H. Yamamoto, H. Sakawaki, T. Miura, T. Tokusumi, T. Shu, T. Matano, Therapeutic vaccine-mediated Gag-specific CD8(+) T-cell induction under anti-retroviral therapy augments anti-virus efficacy of CD8(+) cells in simian immunodeficiency virus-infected macaques, 2020, Sci Rep, 10(1):11394. 10.1038/s41598-020-68267-w.
https://doi.org/10.1038/s41598-020-68267-w

H. Ishii, K. Terahara, T. Nomura, A. Takeda, M. Okazaki, H. Yamamoto, T. Tokusumi, T. Shu, T. Matano, A Novel Immunogen Selectively Eliciting CD8(+) T Cells but Not CD4(+) T Cells Targeting Immunodeficiency Virus Antigens, 2020, J Virol, 94(8): e01876-19.
https://doi.org/10.1128/JVI.01876-19

T.T.T. Hau, M. Nakamura-Hoshi, Y. Kanno, T. Nomura, M. Nishizawa, S. Seki, H. Ishii, A. Kawana-Tachikawa, W.W. Hall, L.A. Nguyen Thi, T. Matano, H. Yamamoto, CD8(+) T cell-based strong selective pressure on multiple simian immunodeficiency virus targets in macaques possessing a protective MHC class I haplotype, Biochem Biophys Res Commun, 2019, 512(2):213-217.
https://doi.org/10.1016/j.bbrc.2019.03.003

S. Seki*, T. Nomura*, M. Nishizawa*, H. Yamamoto, H. Ishii, S. Matsuoka, T. Shiino, H. Sato, K. Mizuta, H. Sakawaki, T. Miura, T.K. Naruse, A. Kimura, T. Matano, In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts, PLoS Pathog, 2017, 13(9):e1006638.
https://doi.org/10.1371/journal.ppat.1006638

H. Yamamoto, S. Iseda, T. Nakane, T. Nomura, N. Takahashi, S. Seki, M. Nakamura, H. Ishii, T. Matano, Augmentation of anti-simian immunodeficiency virus activity in CD8+ cells by neutralizing but not nonneutralizing antibodies in the acute phase, AIDS 30 (2016) 2391-2394.
http://doi.org.10.1097/QAD.0000000000001221

H. Ishii, S. Matsuoka, T. Nomura, M. Nakamura, T. Shiino, Y. Sato, N. Iwata-Yoshikawa, H. Hasegawa, K. Mizuta, H. Sakawaki, T. Miura, Y. Koyanagi, T.K. Naruse, A. Kimura, T. Matano, Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8(+) T-cell frequencies in a macaque AIDS model, Sci Rep 6 (2016) 30153. 10.1038/srep30153.
http://doi.org/10.1038/srep30153

S. Iseda, N. Takahashi, H. Poplimont, T. Nomura, S. Seki, T. Nakane, M. Nakamura, S. Shi, H. Ishii, S. Furukawa, S. Harada, T.K. Naruse, A. Kimura, T. Matano, H. Yamamoto, Biphasic CD8+ T-Cell Defense in Simian Immunodeficiency Virus Control by Acute-Phase Passive Neutralizing Antibody Immunization, J Virol 90 (2016) 6276-6290. 10.1128/JVI.00557-16.
https://doi.org/10.1128/JVI.00557-16

Y. Abe, T. Tamura, S. Torii, S. Wakamori, M. Nagai, K. Mitsuhashi, J. Mine, Y. Fujimoto, N. Nagashima, F. Yoshino, Y. Sugita, T. Nomura, M. Okamatsu, H. Kida, Y. Sakoda, Genetic and antigenic characterization of bovine viral diarrhea viruses isolated from cattle in Hokkaido, Japan, J Vet Med Sci 78 (2016) 61-70. 10.1292/jvms.15-0186.
https://doi.org/10.1292/jvms.15-0186

T. Nomura, H. Yamamoto, H. Ishii, H. Akari, T.K. Naruse, A. Kimura, T. Matano, Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers, PLoS Pathog 11 (2015) e1005247.
https://doi.org/10.1371/journal.ppat.1005247

K. Terahara, H. Ishii, T. Nomura, N. Takahashi, A. Takeda, T. Shiino, Y. Tsunetsugu-Yokota, T. Matano, Vaccine-induced CD107a+ CD4+ T cells are resistant to depletion following AIDS virus infection, J Virol 88 (2014) 14232-14240.
https://doi.org/10.1128/JVI.02032-14

T. Nomura, H. Yamamoto, N. Takahashi, T.K. Naruse, A. Kimura, T. Matano, Identification of SIV Nef CD8(+) T cell epitopes restricted by a MHC class I haplotype associated with lower viral loads in a macaque AIDS model, Biochem Biophys Res Commun 450 (2014) 942-947.
https://doi.org/10.1016/j.bbrc.2014.06.072

N. Iwamoto, N. Takahashi, S. Seki, T. Nomura, H. Yamamoto, M. Inoue, T. Shu, T.K. Naruse, A. Kimura, T. Matano, Control of simian immunodeficiency virus replication by vaccine-induced Gag- and Vif-specific CD8+ T cells, J Virol 88 (2014) 425-433. 10.1128/JVI.02634-13.
https://doi.org/10.1128/JVI.02634-13

N. Takahashi, T. Nomura, Y. Takahara, H. Yamamoto, T. Shiino, A. Takeda, M. Inoue, A. Iida, H. Hara, T. Shu, M. Hasegawa, H. Sakawaki, T. Miura, T. Igarashi, Y. Koyanagi, T.K. Naruse, A. Kimura, T. Matano, A novel protective MHC-I haplotype not associated with dominant Gag-specific CD8+ T-cell responses in SIVmac239 infection of Burmese rhesus macaques, PLoS One 8 (2013) e54300. 10.1371/journal.pone.0054300.
https://doi.org/10.1371/journal.pone.0073117

T. Nakane, T. Nomura, S. Shi, M. Nakamura, T.K. Naruse, A. Kimura, T. Matano, H. Yamamoto, Limited impact of passive non-neutralizing antibody immunization in acute SIV infection on viremia control in rhesus macaques, PLoS One 8 (2013) e73453. 10.1371/journal.pone.0073453.
https://doi.org/10.1371/journal.pone.0073453

T. Tamura, Y. Sakoda, F. Yoshino, T. Nomura, N. Yamamoto, Y. Sato, M. Okamatsu, N. Ruggli, H. Kida, Selection of classical swine fever virus with enhanced pathogenicity reveals synergistic virulence determinants in E2 and NS4B, J Virol 86 (2012) 8602-8613. 10.1128/JVI.00551-12.
https://doi.org/10.1128/JVI.00551-12

Y. Sakoda, H. Wakamoto, T. Tamura, T. Nomura, M. Naito, H. Aoki, H. Morita, H. Kida, A. Fukusho, Development and evaluation of indirect enzyme-linked immunosorbent assay for a screening test to detect antibodies against classical swine fever virus, Jpn J Vet Res 60 (2012) 85-94.
https://pubmed.ncbi.nlm.nih.gov/23094583/

T. Nomura, H. Yamamoto, T. Shiino, N. Takahashi, T. Nakane, N. Iwamoto, H. Ishii, T. Tsukamoto, M. Kawada, S. Matsuoka, A. Takeda, K. Terahara, Y. Tsunetsugu-Yokota, N. Iwata-Yoshikawa, H. Hasegawa, T. Sata, T.K. Naruse, A. Kimura, T. Matano, Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in burmese rhesus macaques, J Virol 86 (2012) 6481-6490.
https://doi.org/10.1128/JVI.07077-11

T. Nomura, T. Matano, Association of MHC-I genotypes with disease progression in HIV/SIV infections, Front Microbiol 3 (2012) 234.
https://doi.org/10.3389/fmicb.2012.00234

K. Kurihara, Y. Takahara, T. Nomura, H. Ishii, N. Iwamoto, N. Takahashi, M. Inoue, A. Iida, H. Hara, T. Shu, M. Hasegawa, C. Moriya, T. Matano, Immunogenicity of repeated Sendai viral vector vaccination in macaques, Microbes Infect 14 (2012) 1169-1176.
https://doi.org/10.1016/j.micinf.2012.07.016