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Research articles

Updated April 26, 2022

NAA Ntim, H. Ishii, M. Jomori, H. Yamamoto, T. Matano, T. Nomura , Hierarchy of multiple viral CD8 (+) T-cell epitope mutations in sequential selection in simian immunodeficiency infection, Biochem Biophys Res Commun, 2022 , 607: 124-130.

https://doi.org/10.1016/j.bbrc.2022.03.108

H. Ishii, K. Terahara, T. Nomura , M. Okazaki, H. Yamamoto, T. Shu, H. Sakawaki, T. Miura, DI Watkins, T. Matano, Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag / Vif-specific CD8 (+) T cells but not CD4 (+) T cells, Mol Ther, 2022, in press

https://doi.org/10.1016/j.ymthe.2022.02.023

H. Ishii *, T. Nomura *, H. Yamamoto, M. Nishizawa, TT Thu Hau, S. Harada, S. Seki, M. Nakamura-Hoshi, M. Okazaki, S. Daigen, A. Kawana-Tachikawa, N. Nagata, N. Iwata-Yoshikawa, N. Shiwa, T. Suzuki, ES Park, M. Ken, T. Onodera, Y. Takahashi, K. Kusano, R. Shimazaki, Y. Suzaki, Y. Ami, T . Matano, Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8 (+) T cell responses, Cell Rep Med, 2022, 3 (2): 100520.

https://doi.org/10.1016/j.xcrm.2022.100520

TTT Hau, Y. Kanno, M. Nishizawa, T. Nomura , T. Matano, H. Yamamoto, Nef-specific CD107a (+) CD4 (+) T-cell responses in a rhesus macaque (Macaca mulatta) showing partial simian immunodeficiency virus control following passive neutralizing antibody infusion, J Med Primatol, 2022, 51 (1): 56-61.

https://doi.org/10.1111/jmp.12551

T. Nomura , H. Yamamoto, M. Nishizawa, TTT Hau, S. Harada, H. Ishii, S. Seki, M. Nakamura-Hoshi, M. Okazaki, S. Daigen, A. Kawana-Tachikawa, N. Nagata , N. Iwata-Yoshikawa, N. Shiwa, S. Iida, H. Katano, T. Suzuki, ES Park, K. Maeda, Y. Suzaki, Y. Ami, T. Matano, Subacute SARS-CoV-2 replication can be controlled in the absence of CD8 + T cells in cynomolgus macaques, PLoS Pathog, 2021, 17 (7): e1009668.

https://doi.org/10.1371/journal.ppat.1009668

Y. Kanno, TTT Hau, R. Kurokawa, T. Nomura , M. Nishizawa, T. Matano, H. Yamamoto, Late-phase dominance of a single epitope-specific CD8 + T-cell response in passive neutralizing antibody-infused simian immunodeficiency virus controllers, AIDS, 2021, 35 (14): 2281-2288.

https://doi.org/10.1097/QAD.0000000000003013

M. Nakamura-Hoshi, Y. Takahara, S. Matsuoka, H. Ishii, S. Seki, T. Nomura , H. Yamamoto, H. Sakawaki, T. Miura, T. Tokusumi, T. Shu, T. Matano, Therapeutic vaccine-mediated Gag-specific CD8 (+) T-cell induction under anti-retroviral therapy augments anti-virus efficacy of CD8 (+) cells in simian immunodeficiency virus-infected macaques, 2020, Sci Rep, 10 (1): 11394 . 10.1038 / s41598-020-68267-w.

https://doi.org/10.1038/s41598-020-68267-w

H. Ishii, K. Terahara, T. Nomura, A. Takeda, M. Okazaki, H. Yamamoto, T. Tokusumi, T. Shu, T. Matano, A Novel Immunogen Selectively Eliciting CD8 (+) T Cells but Not CD4 (+) T Cells Targeting Immunodeficiency Virus Antigens, 2020, J Virol, 94 (8): e01876-19.

https://doi.org/10.1128/JVI.01876-19

TTT Hau, M. Nakamura-Hoshi, Y. Kanno, T. Nomura , M. Nishizawa, S. Seki, H. Ishii, A. Kawana-Tachikawa, WW Hall, LA Nguyen Thi, T. Matano, H. Yamamoto, CD8 (+) T cell-based strong selective pressure on multiple simian immunodeficiency virus targets in macaques possessing a protective MHC class I haplotype, Biochem Biophys Res Commun, 2019, 512 (2): 213-217.

https://doi.org/10.1016/j.bbrc.2019.03.003

S. Seki *, T. Nomura *, M. Nishizawa *, H. Yamamoto, H. Ishii, S. Matsuoka, T. Shiino, H. Sato, K. Mizuta, H. Sakawaki, T. Miura, TK Naruse, A. Kimura, T. Matano, In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts, PLoS Pathog, 2017, 13 (9): e1006638.

https://doi.org/10.1371/journal.ppat.1006638

H. Yamamoto, S. Iseda, T. Nakane, T. Nomura , N. Takahashi, S. Seki, M. Nakamura, H. Ishii, T. Matano, Augmentation of anti-simian immunodeficiency virus activity in CD8 + cells by neutralizing but not nonneutralizing antibodies in the acute phase, AIDS 30 (2016) 2391-2394.

http://doi.org.10.1097/QAD.0000000000001221

H. Ishii, S. Matsuoka, T. Nomura , M. Nakamura, T. Shiino, Y. Sato, N. Iwata-Yoshikawa, H. Hasegawa, K. Mizuta, H. Sakawaki, T. Miura, Y. Koyanagi, TK Naruse, A. Kimura, T. Matano, Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8 (+) T-cell frequencies in a macaque AIDS model, Sci Rep 6 (2016) 30153. 10.1038 / srep 30153.

http://doi.org/10.1038/srep30153

S. Iseda, N. Takahashi, H. Poplimont, T. Nomura , S. Seki, T. Nakane, M. Nakamura, S. Shi, H. Ishii, S. Furukawa, S. Harada, TK Naruse, A. Kimura , T. Matano, H. Yamamoto, Biphasic CD8 + T-Cell Defense in Simian Immunodeficiency Virus Control by Acute-Phase Passive Neutralizing Antibody Immunization, J Virol 90 (2016) 6276-6290. 10.1128 / JVI.00557-16.

https://doi.org/10.1128/JVI.00557-16

Y. Abe, T. Tamura, S. Torii, S. Wakamori, M. Nagai, K. Mitsuhashi, J. Mine, Y. Fujimoto, N. Nagashima, F. Yoshino, Y. Sugita, T. Nomura , M. Okamatsu, H. Kida, Y. Sakoda, Genetic and antigenic characterization of bovine viral diarrhea viruses isolated from cattle in Hokkaido, Japan, J Vet Med Sci 78 (2016) 61-70. 10.1292 / jvms.15-0186.

https://doi.org/10.1292/jvms.15-0186

T. Nomura , H. Yamamoto, H. Ishii, H. Akari, TK Naruse, A. Kimura, T. Matano, Broadening of Virus-Specific CD8 + T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers, PLoS Pathog 11 (2015) e1005247.

https://doi.org/10.1371/journal.ppat.1005247

K. Terahara, H. Ishii , T. Nomura, N. Takahashi, A. Takeda, T. Shiino, Y. Tsunetsugu-Yokota, T. Matano, Vaccine-induced CD107a + CD4 + T cells are resistant to depletion following AIDS virus infection, J Virol 88 (2014) 14232-14240.

https://doi.org/10.1128/JVI.02032-14

T. Nomura , H. Yamamoto, N. Takahashi, TK Naruse, A. Kimura, T. Matano, Identification of SIV Nef CD8 (+) T cell epitopes restricted by a MHC class I haplotype associated with lower viral loads in a macaque AIDS model, Biochem Biophys Res Commun 450 (2014) 942-947.

https://doi.org/10.1016/j.bbrc.2014.06.072

N. Iwamoto, N. Takahashi, S. Seki, T. Nomura , H. Yamamoto, M. Inoue, T. Shu, TK Naruse, A. Kimura, T. Matano, Control of simian immunodeficiency virus replication by vaccine-induced Gag --and Vif-specific CD8 + T cells, J Virol 88 (2014) 425-433. 10.1128 / JVI.02634-13.

https://doi.org/10.1128/JVI.02634-13

N. Takahashi, T. Nomura , Y. Takahara, H. Yamamoto, T. Shiino, A. Takeda, M. Inoue, A. Iida, H. Hara, T. Shu, M. Hasegawa, H. Sakawaki, T. Miura, T. Igarashi, Y. Koyanagi, TK Naruse, A. Kimura, T. Matano, A novel protective MHC-I haplotype not associated with dominant Gag-specific CD8 + T-cell responses in SIVmac239 infection of Burmese rhesus macaques, PLoS One 8 (2013) e54300. 10.1371 / journal.pone.0054300.

https://doi.org/10.1371/journal.pone.0073117

T. Nakane, T. Nomura , S. Shi, M. Nakamura, TK Naruse, A. Kimura, T. Matano, H. Yamamoto, Limited impact of passive non-neutralizing antibody immunization in acute SIV infection on viremia control in rhesus macaques , PLoS One 8 (2013) e73453. 10.1371 / journal.pone.0073453.

https://doi.org/10.1371/journal.pone.0073453

T. Tamura, Y. Sakoda, F. Yoshino, T. Nomura , N. Yamamoto, Y. Sato, M. Okamatsu, N. Ruggli, H. Kida, Selection of classical swine fever virus with enhanced pathogenicity reveals synergistic virulence determinants in E2 and NS4B, J Virol 86 (2012) 8602-8613. 10.1128 / JVI.00551-12.

https://doi.org/10.1128/JVI.00551-12

Y. Sakoda, H. Wakamoto, T. Tamura, T. Nomura , M. Naito, H. Aoki, H. Morita, H. Kida, A. Fukusho, Development and evaluation of indirect enzyme-linked immunosorbent assay for a screening test to detect antibodies against classical swine fever virus, Jpn J Vet Res 60 (2012) 85-94.

https://pubmed.ncbi.nlm.nih.gov/23094583/

T. Nomura , H. Yamamoto, T. Shiino, N. Takahashi, T. Nakane, N. Iwamoto, H. Ishii, T. Tsukamoto, M. Kawada, S. Matsuoka, A. Takeda, K. Terahara, Y. Tsunetsugu-Yokota, N. Iwata-Yoshikawa, H. Hasegawa, T. Sata, TK Naruse, A. Kimura, T. Matano, Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in burmese rhesus macaques, J Virol 86 (2012) 6481-6490.

https://doi.org/10.1128/JVI.07077-11

T. Nomura , T. Matano, Association of MHC-I genotypes with disease progression in HIV / SIV infections, Front Microbiol 3 (2012) 234.

https://doi.org/10.3389/fmicb.2012.00234

K. Kurihara, Y. Takahara, T. Nomura , H. Ishii, N. Iwamoto, N. Takahashi, M. Inoue, A. Iida, H. Hara, T. Shu, M. Hasegawa, C. Moriya, T. Matano, Immunogenicity of repeated Sendai viral vector vaccination in macaques, Microbes Infect 14 (2012) 1169-1176.

https://doi.org/10.1016/j.micinf.2012.07.016

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Books, etc.

Takushi Nomura . "SARS-CoV-2 Infectious Disease Research Using Monkeys". Obelisk. 2021. 26 (2) 12-17.

https://www.hamri.co.jp/obelisk Information magazine "Obelisk" site (review in Japanese)

Takushi Nomura . "Analysis of long-term viral replication control mechanism using sal AIDS model". Journal of Japan AIDS Society 19, 144-149, 2017

review in Japanese

Takushi Nomura , Tetsuro Matano. "Forefront of AIDS Research". Obelisk 22 (1), 2017

https://www.hamri.co.jp/obelisk Information magazine "Obelisk" site (review in Japanese)

Takushi Nomura , Tetsuro Matano. HIV Mucosal Infection and Host Immunity. Experimental Medicine 34 (13), 2162-2166, 2016

​

Takushi Nomura , Tetsuro Matano. Logic of AIDS Vaccine Development. Virus 59 (2), 267-276, 2009

review in Japanese

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